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Title of Journal: Cell Biochem Biophys

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Abbravation: Cell Biochemistry and Biophysics

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Springer US

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DOI

10.1002/chin.200336242

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1559-0283

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Oxymatrine Extracted from Emphasis Type="Italic"

Authors: Jianghua Wei Yin Zhu Gang Xu Fan Yang Zhe Guan Mao Wang Yonghong Fang
Publish Date: 2014/07/06
Volume: 70, Issue: 2, Pages: 1439-1444
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Abstract

Oxymatrine one of the most active components of the ethanol extracts from Sophora flavescens is known for its potent antitumor activity both in vitro and in vivo However the mechanism of its action in mediating the cell apoptosis remains elusive In this study we investigated the proliferation inhibitory and apoptotic activities of oxymatrine against human osteosarcoma MG63 cells The compound was found to markedly and dosedependently inhibit the cell proliferation determined by 5bromo2deoxyuridine incorporation Oxymatrine also induced the cell apoptosis in a dose and timedependent manner as showed by the annexin VFITC/PI double staining and TUNEL assay Furthermore a disruption of mitochondrial membrane potential and an upregulation of cleaved caspases3 and9 and downregulation of Bax/Bcl2 was evidenced in the oxymatrinetreated cells These proteins have been known to play a pivotal role in the regulation of apoptosis In conclusion these observations indicate of the oxymatrine potential as an effective antitumor agent against osteosarcoma Moreover the compound appears to exert its antitumor action by stimulating the caspasetriggered signaling pathway

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