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Title of Journal: Cell Biochem Biophys

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Abbravation: Cell Biochemistry and Biophysics

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Springer US

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DOI

10.1002/cber.19210540940

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1559-0283

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A Novel Urinary Metabolite Signature for Noninvas

Authors: Wei Zhang Xinan Zhang
Publish Date: 2015/05/24
Volume: 72, Issue: 3, Pages: 661-667
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Abstract

Poststroke depression PSD is the most common psychiatric complication in stroke survivors that has been associated with increased physical disability distress poor rehabilitation and suicidal ideation However there are still no biomarkers available to support objective laboratory testing for this disorder Here a GC–MSbased urinary metabolomics approach was used to characterize the urinary metabolic profiling of PSD stroke subjects and nonPSD health controls subjects in order to identify and validate urinary metabolite biomarkers for PSD Six metabolites azelaic acid glyceric acid pseudouridine 5hydroxyhexanoic acid tyrosine and phenylalanine were defined as biomarkers A combined panel of these six urinary metabolites could effectively discriminate between PSD subjects and nonPSD subjects achieving an area under the receiveroperating characteristic curve AUC of 0961 in a training set n = 72 PSD subjects and n = 146 nonPSD subjects Moreover this urinary biomarker panel was capable of discriminating blinded test samples n = 58 PSD patients and n = 109 nonPSD subjects with an AUC of 0954 These findings suggest that a urinebased laboratory test using these biomarkers may be useful in the diagnosis of PSD


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