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Title of Journal: Cell Biochem Biophys

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Abbravation: Cell Biochemistry and Biophysics

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Springer US

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DOI

10.1007/bf00278586

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1559-0283

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Effects of NMDAReceptor Antagonist on the Express

Authors: Hongbin Fan Xiaoquan Li Wei Wang Qingwei Lai Xiaohong Tang Dianshuai Gao Xiaoxing Yin Tiejun Xu
Publish Date: 2015/05/23
Volume: 73, Issue: 2, Pages: 323-330
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Abstract

Neonatal hypoxia–ischemia brain damage is an important cause of death by affecting prognosis of neural diseases It is difficult to find effective methods of prevention and treatment due to the complexity of its pathogenesis Nmethyldaspartate NMDA as an excitotoxicity amino acids has proven to play an important role in hypoxic–ischemic However the exact effects of the NMDA subunits NR2A and NR2B during hypoxic–ischemic have not been investigated in detail Therefore we sought to study whether the NMDA receptor antagonist could confer neuroprotective effects in a neonatal rat hypoxia–ischemia model The effects of intraperitoneal injections of different drugs namely MK801 05 mg/kg NVPAAM077 5 mg/kg and Ro256981 5 mg/kg on the expressions of antiapoptotic protein Bcl2 and apoptosis protein Bax in the subventricular zone were analyzed by immunohistochemical staining to explore the roles of NMDA subunits NR2A and NR2B in hypoxic–ischemic We found that the NR2B antagonist Ro256981 could inhibit hypoxic–ischemic with the increasing Bcl2 expression NR2A antagonists NVPAAM077 can increase cerebral hypoxia–ischemia in neonatal rats promoting the expression of apoptotic protein Bax

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