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Title of Journal: Cell Biochem Biophys

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Abbravation: Cell Biochemistry and Biophysics

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Springer US

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DOI

10.1007/978-1-4020-8466-9_7

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ISSN

1559-0283

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Transglutaminase2 is Involved in Cell Apoptosis o

Authors: Wei Wang Xiao Li Xiangzhen Han Fanbin Meng Zhenxing Wang Yongqing Zhai Dongsheng Zhou
Publish Date: 2015/01/06
Volume: 72, Issue: 1, Pages: 283-288
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Abstract

Osteosarcoma is the most common type of solid bone cancer which is the second leading cause of cancerrelated death Hypoxia is an ordinary phenomenon in solid tumor tissues and can induce cell apoptosis but the specific molecular mechanism remains unclear In this study we explored the effect and the molecular mechanism of Transglutaminase 2 TG2 on cell apoptosis in osteosarcoma U2OS cells under hypoxia We found the enzymatic activity of TG2 is significantly increased and the expression of TG2 is remarkably upregulated under hypoxia condition Cell apoptotic rate is markedly increased upon knockdown of TG2 by siRNA under hypoxia We further investigated the mechanism of cell apoptosis and found Bax protein is significantly increased after depletion of TG2 under hypoxia Moreover our data also show that cytochrome C Cyt C is significantly increased in cytoplasm and markedly decreased in mitochondria of U2OS cells after depletion of TG2 under hypoxia Our results suggest that TG2 can inhibit tumor cell apoptosis through downregulation of Bax and prevention of release Cyt C from mitochondria into cytoplasm

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