Journal Title
Title of Journal: Cell Biochem Biophys
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Abbravation: Cell Biochemistry and Biophysics
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Authors: Kai Jiang Ming Su Xiangqian Zhao Yongwei Chen Wenzhi Zhang Jing Wang Jiahong Dong Zhiqiang Huang
Publish Date: 2013/08/27
Volume: 68, Issue: 3, Pages: 547-554
Abstract
The main objective of this study is to assess the feasibility and safety of treating hepatocellular carcinoma HCC proximal to the gallbladder using laparoscopic radiofrequency ablation RFA Surgical ablation of tumor located adjacent to the gallbladder may damage the gallbladder wall even with a laparoscope and this ablation method is not precise and incomplete and is frequently combined with alcohol injections with need for further RFA treatment Four patients were included in this study with typical HCC where the tumor was present on the left right or bed side surrounding the gallbladder The gallbladder was not separated or removed during larascopic inspection In the RFA treatment procedure the tumor lesion was preheated for 10 min and heating was continued for 20 min The integrity of the gallbladder wall was properly maintained A followup to check for possible local recurrence was carried out 1 year after the RFA The goal of “oneoff” tumor complete RFA is to achieve thorough ablation of the tumor in a single treatment and limiting the possibility of recurrence within 6 months Seven days after RFA liver functions of all the patients returned to nearpreoperative levels The patients experienced slight pain in the upper right abdomen which disappeared in 2–3 days Results of B ultrasound on days 3–5 showed thickening of the periphery of the ablation area without significant effusion Enhanced CT on day 3 showed that RFA lowdensity area completely covered the lesions No significant abnormality was observed in the gallbladder and its vicinity One month after the surgery B ultrasound and CT examination revealed no significant abnormalities All patients had an intact gallbladder and no extrahepatic or intrahepatic bile duct dilatation occurred There was no evidence of damage to the bile duct or the vessels Followup for 18–32 months found that all patients were in good condition “Oneoff” complete RFA can be safely implemented to ablate HCC close to the gallbladder with the assistance of a laparoscope while maintaining integrity and continuity of the gallbladder and without the need for secondary treatments
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