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Title of Journal: Cell Biochem Biophys

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Abbravation: Cell Biochemistry and Biophysics

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Springer US

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DOI

10.1007/bf00339589

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1559-0283

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Sema4D Knockdown in Oligodendrocytes Promotes Func

Authors: HongLei Zhang Jing Wang Long Tang
Publish Date: 2013/08/15
Volume: 68, Issue: 3, Pages: 489-496
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Abstract

Semaphorin4D Sema4D belongs to Semaphorins family and is secreted and membranebound protein Its function on angiogenesis and axon regeneration makes it an ideal therapeutic target for spinal cord injury SCI Here we examined Sema4D expression profile by realtime PCR and western blot and found Sema4D was upregulated after SCI In vitro study showed Sema4D was not only expressed in oligodendrocytes but also in endothelial cells ECs Hypoxia can mimic Sema4D upregulation in both cell lines Moreover overexpression of Sema4D through lentivirus in ECs promoted tube formation However Sema4D overexpression in oligodendrocytes precursor cells OPCs inhibited neuron myelination in neuronoligodendrocyte coculture system Therefore Sema4D knockdown in OPCs was applied in SCI rats The results indicated that Sema4D knockdown significantly promoted functional recovery with blood–brain barrier score Taken together our data suggest that specific Sema4D knockdown in oligodendrocytes without disturbing its angiogenesis effect can be a beneficial strategy for SCI treatmentThis study was supported by National Natural Science Foundation No 31100301 National Natural Science Foundation No 81350110242 Shanxi Natural Science Foundation No 2012JQ7025 Research Funds for the Central Universities No XJJ2011065 and 2012jdhz43 Science and Technology Project of Xi’an University of Technology No 106211112 Startup funds of Teacher with PhD No 106211202 and the PhD Programs Foundation of Ministry of Education of China No 20126118120014

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