Authors: Zeli Han Chengyong Zhou Baochun Sun Qinghong Yan Jinghong Zhang
Publish Date: 2014/07/09
Volume: 70, Issue: 3, Pages: 1573-1578
Abstract
In the present study the effects of the cotransfer of the tumor growth inhibitor 4 gene ING4 together with the Oncostatin M OSM were investigated on tumor regression and subsequent tumor recurrence We constructed a recombinant adenovirus carrying ING4 and OSM which could induce highlevel expression of these three genes in NPC CNE1 cells AdING4 AdOSM and AdING4OSM infection all inhibited the growth of CNE1 cells in vitro while the AdING4OSM exerted the strongest inhibitory effect In CNE1 xenograft tumor models mice an intratumoral injection of AdING4 AdOSM and AdING4OSM resulted in a reduced tumor burden compared to normal saline controls Therefore we suggested that the introduction of adenovirusmediated ING4 and OSM genes could synergistically decrease the recurrence or metastases and develop a control of NPC tumors which advocate a promising therapeutic future in NPC treatment
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