Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Cell Biochem Biophys

Search In Journal Title:

Abbravation: Cell Biochemistry and Biophysics

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1016/j.agee.2011.10.022

Search In DOI:

ISSN

1559-0283

Search In ISSN:
Search In Title Of Papers:

Hypothesis Tim3/Galectin9 A New Pathway for Le

Authors: Lei Gao Shicang Yu Xi Zhang
Publish Date: 2014/03/18
Volume: 70, Issue: 1, Pages: 273-277
PDF Link

Abstract

Despite the improvements in chemotherapy about 60  of acute myeloid leukemia AML remission patients still relapse Leukemic stem cells LSCs are the main causes for the relapse and refractory T cell immunoglobulin mucin3 TIM3 a specific surface molecule expressed on LSCs in most types of AML is a candidate for AML LSCtargeted therapies It is important to know how this molecule functions in the maintenance of LSCs and suppression of antitumor immunity Recent data have shown that Tim3 which expresses on T cells can suppress immune responses indirectly by inducing expansion of myeloidderived suppressor cells MDSCs MDSCs at the leukemia site can also differentiate into tumorassociated macrophages TAMs TAMs can promote proliferation and survival of LSCs by the diversion of adaptive immunity and the facilitation of extracellular matrix remodeling angiogenesis and lymphangiogenesis Our previous study in AML patient bone marrow samples showed CD68+ macrophages around AML clone Based on the known evidence and our experimental findings we hypothesize that Tim3 which specifically expresses on LSCs is beneficial for LSCs survival and AML progression by promoting expansion of MDSCs and differentiating into TAMs at the leukemia site


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Oxymatrine Extracted from Sophora flavescens Inhibited Cell Growth and Induced Apoptosis in Human Osteosarcoma MG-63 Cells In Vitro
  2. Growth Inhibition and Apoptosis of Neuroblastoma Cells Through ROS-Independent MEK/ERK Activation by Sulforaphane
  3. Biochemical Characterization of the Detoxifying Enzyme Glutathione Transferase P1-1 from the Camel Camelus Dromedarius
  4. Spectroscopic Determination of Lysozyme Conformational Changes in the Presence of Trehalose and Guanidine
  5. The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance
  6. The Value of Multi-slice CT Imaging in Cardiac Myxomas in Comparison with Follow-Up Screening in Thoracoscopic Surgery
  7. Clinical Factors Associated With the Diagnosis and Progression of Diabetic Nephropathy
  8. Experimental Studies on the Inhibition of Adenovirus-ING4-OSM Therapy on Nasopharyngeal Carcinoma Proliferation In Vitro and In Vivo
  9. A Novel Urinary Metabolite Signature for Non-invasive Post-stroke Depression Diagnosis
  10. Evaluation of Stem Cell-to-Tenocyte Differentiation By Atomic Force Microscopy to Measure Cellular Elastic Moduli
  11. Effects of Atorvastatin on Pathological Changes in Brain Tissue and Plasma MMP-9 in Rats with Intracerebral Hemorrhage
  12. Influence of Novel Nano-Mesoporous Bioactive Glass on the Regulation of IGF-II Gene Expression in Osteoblasts
  13. Association with Leptin Gene c.-2548 G>A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients
  14. The Attenuation of Lung Ischemia Reperfusion Injury by Oxymatrine
  15. Transglutaminase-2 is Involved in Cell Apoptosis of Osteosarcoma Cell Line U2OS Under Hypoxia Condition
  16. Gamma-Aminobutyric Acid Induces Tumor Cells Apoptosis via GABA B R1·β-Arrestins·JNKs Signaling Module
  17. Effects of NMDA-Receptor Antagonist on the Expressions of Bcl-2 and Bax in the Subventricular Zone of Neonatal Rats with Hypoxia–Ischemia Brain Damage
  18. Sema4D Knockdown in Oligodendrocytes Promotes Functional Recovery After Spinal Cord Injury
  19. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer
  20. Association of Arterial Oxygen Saturation and Acute Mountain Sickness Susceptibility: A Meta-analysis
  21. GJB2 as Well as SLC26A4 Gene Mutations are Prominent Causes for Congenital Deafness
  22. “One-off” Complete Radiofrequency Ablation of Hepatocellular Carcinoma Adjacent to the Gallbladder by a Novel Laparoscopic Technique Without Gallbladder Isolation
  23. Modulation, Bioinformatic Screening, and Assessment of Small Molecular Peptides Targeting the Vascular Endothelial Growth Factor Receptor
  24. Mechanism of Two Novel Human GJC3 Missense Mutations in Causing Non-Syndromic Hearing Loss
  25. Effects of Traditional Chinese Medicine Fu Zheng Decoction on the Immunological Function and Clinical Prognosis of the Elderly Patients with Pneumonia
  26. Endostatin Combined with Platinum-Based Chemo-radiotherapy for Advanced Non-small Cell Lung Cancer
  27. Autopsy Report of a 7-Year Old Patient with the Mosaic Trisomy 13
  28. Arthroscopic Tenodesis Through Positioning Portals to Treat Proximal Lesions of the Biceps Tendon
  29. Quantitative Redox Biology: An Approach to Understand the Role of Reactive Species in Defining the Cellular Redox Environment
  30. Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice

Search Result: