Authors: Guoning Guo Guoyan Zhu Wei Sun Changlin Yin Xiaobao Ren Tinggang Wang Minghua Liu
Publish Date: 2014/06/26
Volume: 70, Issue: 2, Pages: 1427-1432
Abstract
Acute mountain sickness AMS is the most common high altitude illnesses experienced during rapid ascent to a higher altitude without prior acclimation It is mainly characterized by a headache which may be accompanied with nausea vomiting anorexia dizziness lethargy fatigue and sleep disturbance If not diagnosed and treated in a timely manner AMS can develop into deadly high altitude pulmonary edema or high altitude cerebral edema In the previous studies of individual variation in susceptibility to AMS arterial oxygen saturation S textO 2 was identified as being associated with AMS However other studies have reported no association between AMS and arterial oxygen saturation In this study the association between S textO 2 and AMS was assessed through a metaanalysis of published data The literature databases PubMed Web of Science LWW Science Direct and Embase were queried for papers published before 15 April 2014 A fixedeffects model and a randomeffects model were applied Revman 50 on the basis of heterogeneity and the study quality was assessed in duplicate Twelve studies with 614 AMS patients and 1025 control subjects were analyzed There was a significant association with differences in S textO 2 and the risk of developing AMS S textO 2 values are associated with AMS incidence
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