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Title of Journal: FEMS Microbiol Lett

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Abbravation: FEMS Microbiology Letters

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Narnia

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DOI

10.1007/bf00534173

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0378-1097

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Fungicidal effect of human lactoferrin against Can

Authors: Soukka Tero Tenovuo Jorma LenanderLumikari Marianne
Publish Date: 1992/01/01
Volume: 90, Issue: 3, Pages: 223-228
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Abstract

Human lactoferrin LF in its ironfree state apo LF killed Candida albicans in a time and dosedependent way The lethal effect was stronger at pH 70 than at pH 55 and maximum inhibition at neutral pH was achieved in 25 min when the fungal cells were exposed to LF in 005 mM KCl at 37°C Fe3+ saturated LF had no fungicidal activity Apo LFmediated killing was also temperaturedependent with enhanced inhibition at higher temperatures 37° 42°C The presence of 1 mM dglucose did not affect the candidacidal activity of apo LF but both phosphate and bicarbonate ions at physiological salivary concentrations completely blocked the antifungal effect Therefore it seems unlikely that LF belongs to the major host defence factors against oral candidosis

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References

citation author=Valenti P citation author=Visca P citation author=Antonini G citation author=Orsi N citation journal title=Mycopathologia citation year=1985 citation volume=89 citation pages=169175

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