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Title of Journal: FEMS Microbiol Lett

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Abbravation: FEMS Microbiology Letters

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Narnia

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DOI

10.1016/0030-4018(81)90120-6

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0378-1097

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Leptospira interrogans and Leptospira peptidoglyca

Authors: Cinco M Vecile E Murgia R Dobrina P Dobrina A
Publish Date: 1996/05/01
Volume: 138, Issue: 2-3, Pages: 211-214
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Abstract

M Cinco E Vecile R Murgia P Dobrina A Dobrina Leptospira interrogans and Leptospira peptidoglycans induce the release of tumor necrosis factor α from human monocytes FEMS Microbiology Letters Volume 138 Issue 23 May 1996 Pages 211–214 https//doiorg/101111/j157469681996tb08159xElevated plasma concentrations of the cytokine tumor necrosis factor α TNFα have been observed in patients affected by leptospirosis In this study we found that a preparation of peptidoglycan of Leptospira interrogans serovar copenhageni was able to induce the release of TNFα from peripheral blood mononuclear cells TNFα induction occurred in a dose dependent manner and was not affected by the endotoxin inhibitor polymixin B This is the first report on induction of TNFα release by a peptidoglycan of spirochetes Our findings are consistent with existing clinical data and provide a potential mechanism for TNFα production

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References

citation title=Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans citation author=Timmerman CP citation author=Mattsson E citation author=MartinezMartinez L citation author=de Graaf L citation author=van Strijp JAG citation author=Verbrugh HA citation author=Verhoef J citation author=Fleer A citation journal title=Infect Immun citation year=1993 citation volume=61 citation pages=41674172

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  5. Molecular cloning and physical mapping of the nitrogenase structural genes from the filamentous, non-heterocystous cyanobacterium Pseudanabaena sp. PCC7409
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  9. Cloning and characterization of a gene encoding a new thermostable hemolysin from Vibrio parahaemolyticus
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  11. Introduction of the mercury transposon Tn501 into Rhizobium japonicum strains 31 and 110
  12. Characterization of glucoamylase from Aspergillus terreus 4
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