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Title of Journal: Mol Neurobiol

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Abbravation: Molecular Neurobiology

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Humana Press Inc

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ISSN

1559-1182

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New Molecular Insights into Cellular Survival and

Authors: Raymond YenYu Lo WoeiCherng Shyu ShinnZong Lin HsiaoJung Wang ShunSheng Chen Hung Li
Publish Date: 2007/09/13
Volume: 35, Issue: 3, Pages: 236-244
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Abstract

Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt–Jakob disease as well as PRNP knock out and transgenic mice Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein In this paper we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Baxmediated cell death and its responses to various environmental stresses including oxidative stress and ischemia Finally we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapiesWe would like to thank Dr Harry Wilson and Ms M Loney for their critical reading of this manuscript This work was supported in part by research grants from ChenHan Foundation for Education Academia Sinica 94M003 National Science Council NSC932314B303009 and Department of Health DOH95DC1103

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  4. Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury
  5. PGE 2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition
  6. Age and Sex Dependent Alteration in Presenilin Expression in Mouse Cerebral Cortex
  7. Determining the Roles of Inositol Trisphosphate Receptors in Neurodegeneration: Interdisciplinary Perspectives on a Complex Topic
  8. Anxiolytic Actions of Motilin in the Basolateral Amygdala
  9. Mdivi-1 Protects Against Ischemic Brain Injury via Elevating Extracellular Adenosine in a cAMP/CREB-CD39-Dependent Manner
  10. MicroRNA Expression Signatures Determine Prognosis and Survival in Glioblastoma Multiforme—a Systematic Overview
  11. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway
  12. Anti-amyloid Aggregation Activity of Natural Compounds: Implications for Alzheimer’s Drug Discovery
  13. TYROBP in Alzheimer’s Disease
  14. Shengmai Formula Ameliorates Pathological Characteristics in AD C. elegans
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