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Title of Journal: Mol Neurobiol

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Abbravation: Molecular Neurobiology

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Publisher

Springer US

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DOI

10.1007/s10556-014-9938-2

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ISSN

1559-1182

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Adoptive Autophagy Activation a MuchNeeded Remed

Authors: A Srivastava V Kumar A Pandey S Jahan D Kumar C S Rajpurohit S Singh V K Khanna A B Pant
Publish Date: 2016/02/18
Volume: 54, Issue: 3, Pages: 1797-1807
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Abstract

The profound significance of autophagy as a cell survival mechanism under conditions of metabolic stress is a wellproven fact Nearly a decadelong research in this area has led scientists to unearth various roles played by autophagy other than just being an auto cell death mechanism It is implicated as a vital cell survival pathway for clearance of all the aberrant cellular materials in case of cellular injury metastasis disease states cellular stress neurodegeneration and so on In this review we emphasise the critical role of autophagy in the environmental stressorsinduced neurotoxicity and its therapeutic implications for the same We also attempt to shed some light on the possible protective role of autophagy in developmental neurotoxicity DNT which is a rapidly growing health issue of the human population at large and hence a point of rising concern amongst researchers The intimate association between DNT and neurodegenerative disorders strongly indicates towards adopting autophagy activation as a muchneeded remedy for DNTFinancial support from Department of Science and Technology Ministry of Science Technology Government of India New Delhi India Grant No SR/SO/Z 36/2007/91/10 Department of Biotechnology Ministry of Science Technology Government of India New Delhi India Grant No 102/IFD/SAN/3533/201415 and Council of Scientific Industrial Research Government of India New Delhi India Grant No BSC0111/INDEPTH/CSIR Network Project is acknowledged

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