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Title of Journal: Mol Neurobiol

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Abbravation: Molecular Neurobiology

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Springer US

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DOI

10.1007/s11664-015-3883-5

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ISSN

1559-1182

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TYROBP in Alzheimer’s Disease

Authors: Jing Ma Teng Jiang Lan Tan JinTai Yu
Publish Date: 2014/07/23
Volume: 51, Issue: 2, Pages: 820-826
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Abstract

Recently studies have provided convincing data that TYRO protein tyrosine kinasebinding protein TYROBP a key regulator in immune systems is significantly upregulated in the brain of patients with Alzheimer’s disease AD TYROBP acts as a signaling adaptor protein for numerous cell surface receptors playing important roles in signal transduction in dendritic cells osteoclasts macrophages and microglia Although several TYROBPrelated cell surface receptors including triggering receptor expressed on myeloid 2 TREM2 signal regulatory protein β1 SIRPβ1 and complement receptor 3 CR3 were found to participate in the pathogenesis of AD the role of TYROBP in AD still remains elusive Emerging piece of evidence has demonstrated that TYROBP could enhance phagocytic activity of microglia which is responsible for the clearance of amyloidβ Aβ peptides and apoptotic neurons TYROBP also participates in suppression of inflammatory responses by repression of microgliamediated cytokine production and secretion In this article we introduce the structure localization and function of TYROBP Meanwhile we review recent articles concerning the association of TYROBP and its related receptors with AD pathogenesis and speculate the possible roles of TYROBP in this disease Based on the potential protective actions of TYROBP in AD pathogenesis targeting TYROBP might provide new opportunities for AD treatmentThis work was supported by the grants from the National Natural Science Foundation of China to LT 81171209 81371406 and JTY 81000544 the grants from the Shandong Provincial Natural Science Foundation to LT ZR2011HZ001 and JTY ZR2010HQ004 the Medicine and Health Science Technology Development Project of Shandong Province to LT 2011WSA02018 and JTY 2011WSA02020 and the Innovation Project for Postgraduates of Jiangsu Province to TJ CXLX13 561

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