Authors: Masoud Selk Ghaffari Omid Dezfoulian Katayoon Oskouizadeh Seyed Javid Aldavood
Publish Date: 2009/03/05
Volume: 18, Issue: 4, Pages: 469-471
Abstract
A 5yearold male cat presented at the clinic with status epilepticus following longterm sodium valproate treatment On clinical examination the cat lost consciousness and had frequent seizures The animal’s condition did not improve by intravenous administration of diazepam Serum biochemical abnormalities included marked uremia and hyperphospatemia A provisional diagnosis of chronic kidney disease was made based on laboratory data Further investigation and treatment was declined by the owner and the cat was euthanized Necropsy was performed and on histopathological examination numerous lesions were observed within some of the glomeruli Specifically metaplasia of the parietal cells was noted with a change from short cuboidal to tall columnar cells within Bowman’s capsule These cells were composed of round to oval vesicular nuclei with prominent nucleoli The underlying basement membrane was thickened and there was evidence of preglomerular fibrosis
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