Journal Title
Title of Journal: Comp Clin Pathol
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Abbravation: Comparative Clinical Pathology
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Publisher
Springer-Verlag
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Authors: Rania M Sami Aml Soliman Nasr Noha Y Ibrahim Dalia O Darweesh Noha M El Hussieny
Publish Date: 2011/07/26
Volume: 21, Issue: 6, Pages: 1407-1415
Abstract
The pathophysiology of nonHodgkin’s lymphoma is still unknown Many cytokines including interleukin10 IL10 play a role in the perpetuation of the disease The aim of the study was to investigate the association of IL10 gene promoter polymorphisms with nonHodgkin lymphoma and to correlate with survival Fifty patients with diffuse large Bcell lymphoma as well as 50 age and sexmatched apparently healthy volunteers were genotyped for biallellic IL10 gene promoter polymorphisms at positions −1082A/G and −3557T/A using polymerase chain reaction–restriction fragment length polymorphism There were highly statistically significant differences between the two studied groups regarding results of IL10 1082A/G polymorphism for homozygous GG and heterozygous AG genotypes p value 00001 but no statistically significant differences regarding homozygous AA genotype p value = 07583 IL10 3575T/A polymorphism revealed highly statistically significant differences between the two groups regarding homozygous TT p value 00001 and heterozygous TA genotypes p value = 00007 but no significant difference found regarding homozygous AA genotype p value = 01622 We did not find any associations between bad prognostic factors and any of the genotypes or alleles frequencies Our results also reported that there was no impact of these polymorphisms on survival of lymphoma patients IL10 1082A/G and 3557T/A polymorphisms could be claimed as independent risk factors for susceptibility to lymphoma regardless of any associated bad prognostic factors and without impact on overall survivalWe would like to express our gratitude to the nursing team of the hematology unit nuclear medicine oncology department Faculty of Medicine Cairo University for helping us in collecting samples from patients after giving their written informed consent
Keywords:
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