Clinical analyses of 379 Japanese and 2 nonJapane

Authors: Tadako Nakatsuji

Publish Date: 2010/06/17

Volume: 20, Issue: 6, Pages: 613-624

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Abstract

To investigate the increased expression of activationinduced cytidine deaminase AID in vascular diseases 379 Japanese and 2 nonJapanese composed of 87 varix 81 arteriosclerosis obliterans ASO 206 aortic aneurysm AA and 7 venous thrombosis VT patients whose ages were ranged from 607 ± 133 to 745 ± 88 years old were analyzed clinically Their coagulation anomalies were described well using their levels of thrombin antithrombin III complex TAT α2plasmin inhibitorplasmin complex PIC and fibrin/fibrinogen degradation productsD dimer FDPDD in all the 4 diseases VT showed the most severe coagulopathy with the highest levels of TAT PIC and FDPDD followed by AA Among the seven VT cases a lymphoplasmacytic hypophysitis IgG4related hypophysitis case and a retroperitoneal fibrosis case combined with malignant lymphoma ML were found Another VT case involving portal vein thrombosis PVT demonstrated a low level 59 of protein C antigen Ag together with ulcerative colitis In the 81 ASO two showed ML combined with gastric cancer GC Cancers were examined in 87 varix 81 ASO and 199 AA cases The frequency of cancer was 9 33/367 in which five cases showed double cancer The most common cancer was gut cancers which were found in 5 cases 20/367 GC was found in 14 cases and intestinal cancers were found in six cases The AA onset of ten GC cases seemed to occur at the same time as the onset of GC 60–70 of which showed postoperative serum amylase elevation Ectopic splenosis aggravated the clinical symptoms in three AA patients who had undergone gastrectomy cholecystectomy or hepatectomy Bleeding hemolysis and thrombosis were main trigger signs in the three AA patients One of the three developed PVT Existing high levels of activationinduced cytidine deaminase AID were judged from severe coagulopathy combined B cell malignancy accompanied autoimmunity the highest frequency of GC and aggravated splenosis AID downregulation was concluded to be an important factor in order to stop vascular disease progressions

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