Journal Title
Title of Journal: Comp Clin Pathol
|
Abbravation: Comparative Clinical Pathology
|
Publisher
Springer London
|
|
|
|
|
|
Authors: Ganiyu Oboh Taiwo M Adewuni Ayokunle O Ademosun Tosin A Olasehinde
Publish Date: 2016/04/02
Volume: 25, Issue: 4, Pages: 749-756
Abstract
Sorghum stem Sorghum bicolor has been in use in traditional medicine systems for the management of neurodegenerative conditions However there is dearth of information on the scientific basis for its use in the treatment of such conditions This study sought to assess the antioxidant activity and effects of phenolic extract from sorghum stem Sorghum bicolor on some cholinergic acetylcholinesterase AChE and purinergic Na+/K+ATPase and ecto5′nucleotidase enzymes associated with neurological conditions Phenolicrich extract was prepared using methanol 1 N HCl 11 v/v mixture and characterized using highperformance liquid chromatographydiode array detector HPLCDAD In vitro tests were used to investigate the effects of the phenolic extract on AChE Na+/K+ATPase and ecto5′nucleotidase activities Furthermore the hydroxyl OH radical scavenging and Fe2+chelating abilities of the extract were investigated HPLCDAD analysis revealed the presence of some phenolic acids such as caffeic acid 12058 mg/g ferulic acid 7645 mg/g gallic acid 1748 mg/g chlorogenic acid 1625 mg/g and flavonoids such as kaempferol 1598 mg/g rutin 5107 mg/g quercetin 26316 mg/g and quercitrin 8921 mg/g in the phenolic extract The extract significantly inhibited AChE and ecto5′nucleotidase activities in a dose dependent manner with IC50 = 2488 μg/ml and IC50 = 3749 μg/ml respectively and increased Na+/K+ATPase activity in a dose dependent manner Furthermore the phenolic extract also scavenged OH radicals and was able to chelate Fe2+ in a dose dependent manner with IC50 = 5427 μg/ml and 1847 μg/ml respectively This study revealed the antioxidant and modulatory effects of phenolic extracts from sorghum stem on some cholinergic and purinergic enzymes
Keywords:
.
|
Other Papers In This Journal:
- A histological study of the outer layer of rabbit fish ( Siganus javus ) eye
- Hereditary xanthinuria and urolithiasis in a domestic shorthair cat
- The dextran sulphate sodium (DSS) model of colitis: an overview
- Responses to training and standardised exercise test in the athlete horse: changes in blood gas profile
- Group B streptococcus colonization of pregnant women: comparative molecular and microbiological diagnosis
- Topical co-administration of flaxseed and pistachio ointment promoted wound healing; evidence for histopathological features
- A serological survey on Borrelia burgdorferi infection among companion dogs in Ahvaz district, southwestern Iran
- The effect of water-soluble fraction of crude oil on serum biochemical changes in the great sturgeon Huso huso
- Pathologic lesions of naturally occurring coccidiosis in sheep and goats
- Histometrical study of the different parts of ureter in one-humped camel
- Association of IL-10 gene promoter polymorphisms and non-Hodgkin lymphoma in Egyptian patients, relation to susceptibility, correlation with survival
- Effects of sutureless amniotic membrane patching with 2-Octyl cyanoacrylate (Dermabond) on experimental corneal alkali burn in dogs
- Detection of minimal residual disease (MRD) in canine lymphoma
- Determination of some normal serum parameters in starry sturgeon ( Acipenser stellatus Pallas, 1771) during spring season
- Experimental infection with Trypanosoma evansi in rams: presence of parasite in semen, investigation of sexual transmission, hematological, and biochemical alterations
- Effects of platelet-rich plasma (PRP) on cutaneous regeneration and wound healing in dogs treated with dexamethasone
- Articular cartilage changes in experimental osteoarthritis in rabbits: MRI and morphological findings
- Comparison of selected biochemical parameters between naturally infected and non-infected goats with Anaplasma ovis
- Metaplasia of the parietal layer of Bowman’s capsule in a cat
- Evaluation of wound healing activity of St. John’s Wort ( Hypericum perfoliatum ) in horses
- Prevalence of Coxiella burnetii in bovine bulk milk samples in southern Iran
- Glutathione S -transferase genotypes and numerical chromosomal aberrations in myeloid neoplasms
- Osmotic fragility of human erythrocytes in vitro using Vipera lebetina venom
- Evaluation of changes in wound assessment parameters associated with contra-lateral spermatic cord as ligature in open and closed pre-scrotal and scrotal castrations
- Selected biochemical values of yearling African blue neck ostriches ( Struthio camelus ) in Iran
- Effect of a single intrastriatal rotenone injection on oxidative stress and neurodegeneration in the rat brain
- Antioxidant preserving effects of l -arginine at reducing the hemodynamic toxicity of gentamicin-induced rat nephrotoxicity: pathological and biochemical findings
- Clinical relevance of angiopoietin-1, angiopoietin-2, and their receptor Tie-2 expression in acute myeloid leukemia
- Clinical analyses of 379 Japanese and 2 non-Japanese patients with venous or arterial vascular diseases: combined B cell anomalies, gastric cancer, and aggravated ectopic splenosis
- Introduce Indian gray mongoose ( Herpestes edwardsii ): as a successful animal model for influenza virus infection (a preliminary study)
- Incidence of cardiomyopathy and collapse in two pregnant mares with history of subacute consumption of organophosphate-exposed Cynodon dactylon hay
- Effects of vitamin C on epididymal sperm quality following experimentally induced copper poisoning in mice
- Humoral immune response in Oreochromis niloticus : modified direct agglutination test
- Clinical aspects, morphometry, and morphology of blood cells of the emu ( Dromaius novaehollandiae ) reared in captivity
- Trichoepithelioma in a neonatal calf
- Maternal and offspring methylenetetrahydrofolate reductase gene C677T polymorphism: does it influence the prevalence of congenital heart defects in Egyptian neonates?
|