Authors: M Mansourian M Namavari A Rahimian S Nazifi M Lotfi S Sadeghzadeh
Publish Date: 2014/12/14
Volume: 24, Issue: 5, Pages: 1139-1145
Abstract
Indian gray mongoose Herpestes edwardsii is native to a large geographic area but there is a lack of data about the biology of this animal In the present investigation the possibility of experimental infection with influenza H1N1 virus in mongoose was studied Ten H edwardsii were gathered Two animals were maintained without inoculation and others were inoculated by nasal route and then euthanized in different situations The inoculated group showed clinical signs of pulmonary disorder Necropsy findings and histopathologic investigation revealed a severe interstitial pneumonia In the next step the virus shedding and direct transmission from the infected animal to others were checked The results showed that virus shedding can occur To our knowledge this is the first description of Indian gray mongoose as an animal model for evaluating the experimental influenza virus infection and it is a successful model for influenza research
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