Effects of plateletrich plasma PRP on cutaneous

Authors: Kamran Sardari Mohamad Reza Emami Hossein Kazemi Ahmad Reza Movasagi Amir Afkhami Goli Abbas Lotfi Sara Malekzadeh

Publish Date: 2010/03/03

Volume: 20, Issue: 2, Pages: 155-162

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Abstract

To evaluate the effects of plateletrich plasma PRP on cutaneous regeneration and wound healing in dogs treated with dexamethasone the present study was undertaken Under general anesthesia six fullthickness skin wounds were created on the back of five male adult dogs symmetrically Left side wounds were left without any treatment and right side wounds were treated topically with PRP jelly Six days before creating the wounds dogs received dexamethasone 05 mg/kg IM and every other day up to day 8 after wounding For macroscopic evaluation digital photographs were taken from wounds In days 10 17 and 24 after wounding skin biopsies were taken from the center and corner of each wounds for hydroxyproline measurement and histopathological evaluation No significant difference was seen in the percentage of wound contraction epithelialization and healing between test and control groups during the study P  005 There were no significant differences between median of hydroxyproline levels between left and right wounds in dogs treated with dexamethasone P  005 There were no significant differences between median of epithelialization inflammatory cell infiltration presence of dermal granulation tissue fibroblast proliferation arrangement of fibroblasts collagen deposition and collagen bundle formation scores in the specimens of left and right wounds P  005 The results of the present study demonstrated that PRP did not have significant effects to promote cutaneous regeneration and wound healing in dogs treated with dexamethasone at least 16 days after last injection

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