Journal Title
Title of Journal: Comp Clin Pathol
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Abbravation: Comparative Clinical Pathology
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Publisher
Springer London
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Authors: Mohammad Reza Farahpour Salar Fathollahpour
Publish Date: 2015/04/09
Volume: 24, Issue: 6, Pages: 1455-1461
Abstract
This study was conducted to compare the traditional prescriptions of flaxseed and Pistacia atlantica oil in wound healing in rabbit Eighty white New Zealand rabbits randomly allocated to five experimental groups n = 16 Two fullthickness skin excisional wounds were created on the thoracolumbar region on each side of the dorsal midline in each rabbit Group 1 was considered as control Group 2 rabbits received nitrofurazone ointment 02 w/w Group 3 animals were treated with P atlantica hull 2 ointment In group 4 rabbits received flaxseed ointment 2 and group 5 was treated with combination of flaxseed 2 + P atlantica hull 2 ointment Animals were anesthetized and the skin of specimens were taken in 3 7 14 and 21 days postoperative Tissue samples were dissected out and quantity of cellular infiltration polymorphonuclear and mononuclear cells new vessels and fibroblast formation and angiogenesis were estimated Also the woundhealing area mm2 was evaluated in 4 8 12 16 and 20 days postoperative According to the result flaxseed and pistachio oil ointment significantly decreased polymorphonuclear and mononuclear cell distribution on day 3 postoperative P 005 Also coadministration of flaxseed + pistachio oil significantly improved new vessel formation compared to other groups P 005 Furthermore flaxseed and pistachio improved subsequent fibroblast distribution in injured rabbit P 005 Moreover rabbits which received the combination of flaxseed + pistachio had better wound healing compared to control group P 005 Our data suggested that coadministration of the pistachio and flaxseed promoted the healing process by shortening inflammation phase elevating cellularity and promoting collagen synthesis
Keywords:
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