Authors: E Furman E H Hooijberg J Leidinger C Zedinger E Leidinger U Giger
Publish Date: 2015/01/30
Volume: 24, Issue: 6, Pages: 1325-1329
Abstract
A 2yearold domestic shorthair cat was presented with a history of hematuria stranguria and intermittent urethral obstruction Urine sedimentation showed hematuria pyuria and yellowbrown amorphous and spherical crystals Upon surgical correction of the obstructed urethra by perineal urethrostomy many dark yellow to grey irregular gravellike to millet grainsized uroliths were found These uroliths were shown to consist of 100 xanthine by crystallography The urinary xanthine concentration was high The cat subsequently developed bilateral nephroliths recurrent urinary tract infections and chronic kidney failure Dietary management with a lowpurine diet failed in part due to poor compliance and the cat was euthanized at 6 years of age Xanthinuria is a rare inborn error of metabolism in cats and some other species but should be considered as a differential diagnosis in cases of feline urolithiasis No associated molecular genetic defect has been elucidated and management of these cases is difficult In the absence of calculi for analysis measuring urinary xanthine concentration can help in diagnosing this metabolic defect
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