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Title of Journal: Comp Clin Pathol

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Abbravation: Comparative Clinical Pathology

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Springer-Verlag

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DOI

10.1016/0020-0891(80)90037-8

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1618-565X

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Clinical relevance of angiopoietin1 angiopoietin

Authors: Safaa M El Karaksy Nancy M El Guindy Heba M Gouda Mervat M Khorshied Iman A Shaheen Reham E Abu Khalil Noha Y Ibrahim
Publish Date: 2010/04/14
Volume: 20, Issue: 4, Pages: 341-347
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Abstract

The angiogenicrelated factors angiopoietin1 and angiopoietin2 and their receptor Tie2 have wideranging effects on tumor behavior that includes angiogenesis and inflammation These multifaceted pathways present a potential target in developing novel inhibition strategies for cancer therapy The present work aimed at detecting the prevalence of expression of angiopoietin1 angiopoietin2 and their receptor Tie2 in 56 Egyptian de novo acute myeloid leukemia AML patients by conventional RTPCR to verify the prognostic impact of their expression on the response to induction chemotherapy Thirty age and sexmatched healthy volunteers were subjected to the same analysis as a control group High expression of Ang1 was detected in the patient group but not the control group AML patients expressing Ang2 either solely or in combination with high Ang1 and/or Tie2 showed unfavorable response to induction chemotherapy either failed induction or death during induction These data provide evidence that the alternation of angiopoietin balance in favor of Ang2 may play a critical role in the pathophysiology of AML Furthermore positive pretherapeutic expression of Ang2 indicates viable unfavorable prognostic marker in AML patients and may be used as a prognostic tool in the riskadaptive management of AML

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