Authors: Giovanna Bruni Vittorio Berbenni Franco Sartor Chiara Milanese Alessandro Girella Dionigio Franchi Amedeo Marini
Publish Date: 2011/04/09
Volume: 108, Issue: 1, Pages: 235-241
Abstract
In this work thermoanalytical diffractometry and microscopy measurements have been performed in order to characterize the effect of high energy milling on a drug active in the migraine prophylaxis and smoke cessation We can assert that the mechanical treatment induces only a partial amorphisation of the solid phase in particular it reduces the crystal order by producing lattice defects which propagate from the surface to the bulk crystal For this reason the DSC is able to detect the presence of ordered solid while the powder Xray diffractometry because of its low penetration depth does not reach the crystalline core of the particles
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