Authors: M R Caira V J Griffith L R Nassimbeni
Publish Date: 2014/01/16
Volume: 51, Issue: 3, Pages: 981-991
Abstract
Thermogravimetric and differential scanning calorimetric traces were recorded for several crystalline hydrated cyclodextrin complexes containing drug substances salts of diclofenac meclofenamate sodium Lmenthol as guests It was possible to reconcile observed thermal events for complex dehydration with three dimensional hydration patterns deduced from available Xray crystal structures of the complexes For complexes containing drug salts strong retention of water molecules is attributed to their coordination to metal ions
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