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Title of Journal: J Therm Anal Calorim

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Abbravation: Journal of Thermal Analysis and Calorimetry

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Springer Netherlands

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DOI

10.1007/bf02170538

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ISSN

1588-2926

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Grinding effect on levofloxacin hemihydrate

Authors: Rafael Nicolay Pereira Cinira Fandaruff Manoela Klüppel Riekes Gustavo A Monti Carlos Eduardo Maduro de Campos Silvia Lucia Cuffini Marcos Antonio Segatto Silva
Publish Date: 2014/10/19
Volume: 119, Issue: 2, Pages: 989-994
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Abstract

The grinding techniques were used in different pharmacotechnical process The control of the effect of grinding in solid state properties of drugs is very important mainly in hydrated drugs Levofloxacin hemihydrate LVF is a good example of this type of compounds and a broad spectrum antibiotic of the fluoroquinolone drug class The samples of LVF with and without grinding were studied using different characterization techniques such as thermogravimetry differential scanning calorimetry fouriertransformed infrared Xray powder diffraction and hot stage microscopy The purpose of the present study was to evaluate the effects of grinding in the dehydration and rehydration processes in levofloxacin hemihydrate After heating the samples lost water molecules and the rehydration process was modified depending on defects due to the grinding At room temperature the complete transformation to the hemihydrate form was detected only for the sample without grinding On the other hand the milled sample showed two phases hydrate and anhydrate forms Therefore the defects in the crystalline structure would cause the irreversible transformationThe authors acknowledge the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES for the financial support Pósgraduação em Farmácia PGFAR—UFSC and Próreitoria de Pósgraduação PRPG The XRPD measurements were carried out at Laboratório de Difração de RaiosX of Universidade Federal de Santa Catarina

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