Authors: Francisco X Campos Mário R S Soares Ailton J Terezo A B Siqueira
Publish Date: 2013/06/22
Volume: 115, Issue: 1, Pages: 167-176
Abstract
Solidstate Mmef compounds where M stands for bivalent Mn Fe Co Ni Cu or Zn and mef is mefenamate have been synthesized and characterized by thermoanalytical and spectroscopic techniques molecular modeling and antioxidant capacity evaluations The TG–DTA and DSC curves show that the cobalt nickel and zinc compounds were hydrated while the manganese iron and copper compounds were anhydrous The results provided information on the composition dehydration thermal stability ligand denticity crystallinity thermal decomposition as well as the gaseous products that evolved during the thermal decomposition of these compounds The thermal stability of the anhydrous compounds depended on the nature of the metal ion and followed the order Ni Mn Zn Co Cu–Fe The antioxidant activity of Mmef was higher than that of mefenamic acid indicating that they are good models in treating a variety of inflammatory diseases and may lead to the development of new drugs
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