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Title of Journal: J Therm Anal Calorim

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Abbravation: Journal of Thermal Analysis and Calorimetry

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Springer Netherlands

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DOI

10.1016/0168-1923(88)90030-5

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1588-2926

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Examination of the peripheral nerve and muscle dam

Authors: Péter Farkas Franciska Könczöl Dénes Lőrinczy
Publish Date: 2016/01/30
Volume: 126, Issue: 1, Pages: 47-53
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Abstract

Polyneuropathy is defined as a simultaneous malfunction of several peripheral nerves which could be a side effect of cancer therapy however this is reported to occur rarely and difficult to prove The purpose of this study was to introduce at the first time the calorimetry in the diagnosis of neuropathy in an experimental animal model Adult guinea pigs n = 55 in 11 different groups were injected intraperitoneally with the dose of cyclophosphamide that is comparable to the human dosage Animals were euthanized nerve ischiadicus and muscle gastrocnemius samples were analyzed by a SETARAM MicroDSC The denaturation temperatures as well as the calorimetric enthalpies were determined The thermal parameters of denaturation of the samples varied depending on the therapeutic cyclophosphamide doses The nerves were more sensitive to chemotherapy compared to the muscles An interesting body side effect of treatment was observed The DSC is an appropriate tool to follow the effects of cyclophosphamide on peripheral nerves and muscles which were found dose dependentThe authors express their thanks to Angéla Dömse for the technical help in the drug treatment of the animals This work was supported by Grants OTKA CO272 for Dénes Lőrinczy The present scientific contribution is dedicated to the 650th anniversary of the foundation of the University of Pécs Hungary

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