Authors: Ali Duzova Fatih Ozaltin Alev Ozon Nesrin Besbas Rezan Topaloglu S Ozen A Bakkaloglu
Publish Date: 2004/04/17
Volume: 23, Issue: 3, Pages: 230-234
Abstract
The aim of this study was to evaluate bone mineral content BMC serum and urinary bone turnover parameters in patients with familial Mediterranean fever FMF an autosomal recessive disease characterized by recurrent episodes of inflammation of serous membranes Demographic characteristics and MEFV mutations were defined in 48 children diagnosed with FMF 23 F 25 M median age 70 years 30–100 We evaluated the blood counts acutephase proteins and serum and urinary bone turnover parameters during attackfree periods The BMC and BA bone area of vertebrae L1–L4 were measured by DEXA Thirtyeight age sex and ethnicitymatched healthy children constituted the control group Mean L1–L4 BMC in Group I patients with two mutations and II patients with no or single mutations were 1549±599 g and 1568±489 g respectively both significantly lower than the mean L1–L4 BMC of control patients which was 1959±67 g p005 Mean L1–L4 BMD in Group I Group II and the control group were 0466±0066 g/cm2 0487±0085 g/cm2 and 0513±0079 g/cm2 respectively Mean zscores in Group I Group II and the control group were –187±074 155±092 and –139±084 respectively Mean L1–L4 BMD and zscore of Group I were lower than in the control group p005 ESR and SAA serum amyloid A levels were higher in Group I patients 283±145 mm/h and 350±62 mg/l in Group I and 205±117 mm/h and 190±68 mg/l in Group II respectively In conclusion FMF patients had lower BMC BMD and zscores than a control group We suggest that decreased BMD BMC and zscore in FMF patients may be secondary to subclinical inflammation
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