Authors: Patompong Ungprasert Prangthip Charoenpong Praveen Ratanasrimetha Charat Thongprayoon Wisit Cheungpasitporn Promporn Suksaranjit
Publish Date: 2014/05/25
Volume: 33, Issue: 8, Pages: 1099-1104
Abstract
Several chronic inflammatory disorders such as rheumatoid arthritis and systemic lupus erythematosus have been shown to increase coronary artery disease CAD risk but the data on systemic sclerosis SSc is unclear We conducted a systematic review and metaanalysis of observational studies that reported odds ratio relative risk hazard ratio or standardized incidence ratio comparing CAD risk in patients with SSc versus nonSSc participants Pooled risk ratio and 95 confidence intervals were calculated using a random effect generic inverse variance method Four studies were identified and included in our data analysis The pooled risk ratio of CAD in patients with SSc was 182 95 CI 140 to 236 The statistical heterogeneity of this metaanalysis was moderate with an I 2 of 73 Our study demonstrated a statistically significant increased CAD risk among patients with SSc
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