Authors: Ashit Syngle Inderjeet Verma Nidhi Garg Pawan Krishan
Publish Date: 2013/04/03
Volume: 32, Issue: 7, Pages: 1059-1064
Abstract
Autonomic nervous system ANS involvement has been studied in systemic lupus erythematosus rheumatoid arthritis systemic sclerosis Sjogren’s syndrome and ankylosing spondylitis but still has not been studied in psoriatic arthritis PsA The aim of this study was to investigate the prevalence and the nature of autonomic neuropathy in patients with PsA Sixteen patients of PsA and 15 age and sex matched control subjects were studied prospectively using a battery of noninvasive tests Cardiovascular autonomic neuropathy CAN was diagnosed by applying four cardiovascular reflex tests and peripheral sympathetic autonomic function was assessed by Sudoscan Patients with PsA had significantly higher heart rate response to standing p = 001 blood pressure response to standing p = 002 and Sudoscan p = 001 when compared with healthy controls Fifty percent n = 8 of the patients with PsA had at least two or more abnormal CAN parasympathetic dysfunction of these 1875 n = 3 of the patients had abnormal parasympathetic and sympathetic dysfunction 687 n = 11 and 25 n = 4 of the patients had at least one abnormal parasympathetic and sympathetic parameters respectively and 375 n = 6 of the patients had moderate sudomotor dysfunction About 187 n = 3 of our parasympathetic dysfunction patients had autonomic symptoms None of healthy volunteers had abnormal ANS dysfunction Heart rate response significantly correlated with erythrocyte sedimentation rate p 005 and Creactive protein p 005 levels In conclusion cardiovascular autonomic and peripheral sympathetic neuropathy occurs in PsA Parasympathetic function is more commonly found to be abnormal than sympathetic function There is no correlation of peripheral sympathetic dysfunction with cardiovascular autonomic neuropathy
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