Authors: Carlo Trevisan Raymond Klumpp Riccardo Compagnoni
Publish Date: 2016/03/16
Volume: 35, Issue: 10, Pages: 2517-2522
Abstract
The aim of this study is to verify the prevalence of risk factors for transient osteoporosis TO in a cohort of patients selected by strict diagnostic criteria Retrospective observational cohort study on outpatients’ data Inclusion criteria were 1 acute onset of pain at a lower limb joint exacerbated by weight bearing 2 no history of trauma tumors rheumatic diseases or infection 3 presence bone marrow edema on MRI in a weight bearing joint without signs of intraarticular lesions 4 no hyperesthesia and/or allodynia and/or sweeting changes The following risk factors were search for in all patients 1 previous episode of TO 2 disorders of bone metabolism 3 cigarette smoke 4 sudden lower limb overuse 5 presence of osteoporosis/osteopenia Twentythree patients 8 females 15 males mean age 484 years fulfilled the inclusion criteria An average of 196 risk factors for TO was present in the cohort The most frequent risk factor was overuse in 15 patients 652 and the second risk factor was bone metabolism disorders in 10 patients 435 Seven patients 304 were heavy smokers more than 20 cigarettes per day and seven patients showed a previous episode of TO Six patients 261 of the overall cohort but 60 of those investigated with DEXA resulted osteoporotic or osteopenic Our results suggest there are risk factors that must be investigated in these patients The presence of these risk factors might support the thesis that their disorder is tied to a decoupling between microdamage accumulation and selfreparative ability of bone tissue The identification of risk factors with a precise diagnostic pathway can accelerate the diagnostic process and reduce recurrences
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