Authors: Jorge RojasSerrano Denisse HerreraBringas Mayra Mejía Hermes Rivero Heidegger MateosToledo José E Figueroa
Publish Date: 2015/07/30
Volume: 34, Issue: 9, Pages: 1563-1569
Abstract
The objectives of the present study were to compare the survival function of antisynthetase syndrome ASS Jo1positive patients with ASS nonJo1 patients all with interstitial lung disease ILD and to evaluate other factors such as the extension of pulmonary disease and the time between the onset of symptoms and diagnosis and its association to survival in a cohort of ASS patients Patients with ASS all with ILD were included At the baseline pulmonary function tests were realized and a highresolution chest tomography was obtained lung inflammation and fibrosis were measured with the Goh score and the Kazerooni index The following autoantibodies were measured Jo1 Ej Oj PL7 and PL12 Patients had to be positive for one of them in order to be included in the study The survival function was estimated and compared with the log rank test and the hazard ratio HR was estimated using Cox regression procedure Fortythree patients were included of which six patients died 14 Patients who died were different in comparison with survivors as regards the frequency of antiJo1 positivity Survivors had antiJo1 autoantibodies more frequently 86 than patients who died 50 The univariate Cox regression analysis identified four variables associated with survival Jo1 status arthritis extent of ground glass and consolidation inflammation in highresolution computed tomography HRCT and baseline forced vital capacity The serological status of patients Jo1positive vs nonJo1 the extent of lung inflammation in the HRCT scan a low forced vital capacity and arthritis are associated with survival in ASS patients
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