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Title of Journal: Clin Rheumatol

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Abbravation: Clinical Rheumatology

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Springer-Verlag

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1434-9949

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Oxidative status in rheumatoid arthritis

Authors: Yesim Ozkan Sevgi YardýmAkaydýn Aylin Sepici Erinc Keskin Vesile Sepici Bolkan Simsek
Publish Date: 2006/03/25
Volume: 26, Issue: 1, Pages: 64-68
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Abstract

The insufficiency of antioxidant defense systems and the acceleration of the oxidative reactions can be results of the prooxidant/antioxidant imbalance in rheumatoid arthritis RA The aim of our study was to investigate the changes in oxidant status by measuring two different parameters one was the level of malondialdehyde MDA as an index of lipid peroxidation and the other was total oxidative status we could then compare our results with the antioxidant status superoxide dismutase SOD enyzme activities All were assessed in 22 patients with active RA and 18 age and gendermatched control subjects While serum MDA levels were significantly increased in patients with RA compared to the control group p003 the total oxidative status levels were decreased in patients with RA compared to the control group p0008 and serum SOD activities did not show any statistical difference between the two groups In conclusion the increased MDA levels in our study may be important as a marker but are not sufficient to conclude that there was an increase in oxidative stress in RA patients because supporting results were not obtained from SOD and oxidative status measurements These results give further support to the concept of oxygen free radicals playing a role in the pathogenesis of chronic inflammatory disorders but we also consider that there is a more complex relationship than has been assumed We think that further studies are needed to clarify these conflicting results

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