Authors: Alaa Sabry Hussein Sheashaa Amr ElHusseini Khaled ElDahshan Mona AbdelRahim Sherief Refat Elbasyouni
Publish Date: 2007/03/06
Volume: 26, Issue: 11, Pages: 1819-1823
Abstract
Cardiovascular events are markedly increased in systemic lupus erythematosus SLE and the mechanism of atherogenesis remains poorly understood Several methods have been employed to assess endothelial function among these is the measurement of biomarkers of endothelial activation and dysfunction intercellular adhesion molecule ICAM1 It has been reported that such biomarkers play a more important role than traditional risk factors in cardiovascular disease The objectives of this study were to determine the level of ICAM1 as markers of endothelial dysfunction in 40 Egyptian patients who have SLE with various degrees of activity and to investigate their relationship to disease activity Sixty people 40 with SLE and 20 healthy as the control group were the subject of this study their clinical disease activity was scored according to the SLE disease activity index SLEDAI and serum sampling was obtained for ICAM1 level assay Renal biopsy was carried out and examined by light microscopy by a pathologist blinded to the clinical activity The mean level of ICAM1 was significantly higher in SLE patients with active disease 82605 ± 3671 Pg/ml compared to those with inactive disease 44133 ± 22519 Pg/ml and the healthy control volunteers 1115 ± 1736 Pg/ml There was a positive correlation between serum ICAM1 and SLEDAI r = 066 A high concentration of soluble ICAM1 in SLE patients with nephritis is reported in this paper Our finding of increased concentrations of ICAM1 in SLE patients with nephritis underlines the importance of inflammation and endothelial involvement in this disease but their predictive value in the disease monitoring need to be further studied
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