Authors: F Yalçınkaya E İnce T Uçar N Özkaya M Tekin A H Elhan E Tutar D H Güriz D Aysev R Gökdemir Ü Doğru N Tümer
Publish Date: 2014/05/12
Volume: 21, Issue: 5, Pages: 378-381
Abstract
Familial Mediterranean fever FMF is an autosomal recessive disorder Although the pathogenesis of the disease is not yet completely understood enhanced acutephase responsiveness is considered to be one of the most important mechanisms The presence of high levels of antistreptolysin O ASO antibodies and streptococcusassociated diseases such as acute poststreptococcal glomerulonephritis AGN and acute rheumatic fever ARF has been reported in patients with FMF In order to better understand the effect of FMF on antistreptococcal antibody response we measured ASO and antideoxyribonuclease B antiDNAse B levels in patients with FMF and compared them with those in healthy controls The study consisted of two parts In the first step antistreptococcal antibody levels were analysed in 44 patients with FMF and 165 healthy children who had no history or clinical evidence of upper respiratory tract infection URTI for the last 4 months In the second step antistreptococcal antibody levels were measured in 15 patients with FMF and 22 healthy controls in response to documented group A βhaemolytic streptococcal pharyngitis In the first part of the study ASO and antiDNAse B levels in patients with FMF were found to be significantly higher than those in healthy controls P0001 In the second part ASO and antiDNAse B titres were found to be significantly higher in patients with FMF than in controls P0001 and 005 respectively 4 weeks after a positive throat culture We concluded that patients with FMF have an exaggerated response to streptococcal antigens and might be prone to poststreptococcal nonsuppurative complications such as ARF
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