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Title of Journal: Clin Rheumatol

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Abbravation: Clinical Rheumatology

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Springer London

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DOI

10.1007/978-3-662-44800-7_3

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1434-9949

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Emphasis Type="Italic"STAT4/Emphasis rs7574865

Authors: Ma de Jesús DuránAvelar Norberto VibancoPérez Raquel Rocío HernándezPacheco América del Carmen CastroZambrano Liliana OrtizMartínez José Francisco ZambranoZaragoza
Publish Date: 2016/05/28
Volume: 35, Issue: 12, Pages: 2909-2914
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Abstract

Rheumatoid arthritis RA is a systemic autoimmune disease in whose etiology genetic factors are known to play an important role Among the genes associated with RA STAT4 could be an important factor in conducting helper T cells toward the proinflammatory Th1 and Th17 lineages The aim of this study is to determine the association of the STAT4 polymorphism rs7574865 with RA disease activity and anticyclic citrullinated peptide CCP antibody levels in a Mexican population Genotyping was carried out using the Taqman® system from Applied Biosystems in 140 patients with RA and 150 healthy subjects Disease activity was evaluated by a rheumatologist using the DAS28 and SpanishHAQDI instruments AntiCCP levels were determined by ELISA Associations of the genotypes of rs7574865 with DAS28 HAQ and antiCCP antibody levels with RA were determined Findings showed that the GT and TT genotypes and the T allele from rs7574865 were all associated as risk factors for RA independently of their antiCCP status An association with moderatetohigh disease activity DAS28 ≥ 32 was also found Additionally patients with the GT or TT genotypes showed lower HAQ values than those who carried the GG genotype No differences in antiCCP antibody levels or DAS28 and genotypes were found This work supports the association of the STAT4 rs7574865 polymorphism with RA and disease activity but not with antiCCP antibody levels in a Mexican populationThis work was supported by the Integral Program for Institutional Improvement PIFI201118MSU0019M05 and the Improvement of Quality of Educational Institutions Program PROFOCIE201418MSU0019M0401 Raquel Rocío Hernández Pacheco was funded as a Fellow of Mexico’s National Science and Technology Council CONACYT while América del Carmen Castro Zambrano was a Fellow of the National Organization for Scholarships for Higher Education of Mexico’s Department of Public Education SEP

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