Authors: Guofeng Li Ning Han Zengchun Li Qingyou Lu
Publish Date: 2013/01/08
Volume: 32, Issue: 5, Pages: 609-615
Abstract
Rheumatoid arthritis RA is recognized as the most crippling or disabling type of arthritis and osteoarthritis OA is the most common form of arthritis These diseases severely reduce the quality of life and cause high socioeconomic burdens However the molecular mechanisms of RA and OA development remain elusive despite intensive research efforts In this study we aimed to identify the potential transcription regulatory relationships between transcription factors TFs and differentially coexpressed genes DCGs in RA and OA respectively We downloaded the gene expression profiles of RA and OA from the Gene Expression Omnibus and analyzed the gene expression using computational methods We identified a set of 4076 DCGs in pairwise comparisons between RA and OA patients RA and normal donors NDs or OA and ND After regulatory network construction and regulatory impact factor analysis we found that EGR1 NFE2L1 and NFYA were crucial TFs in the regulatory network of RA and NFYA CBFB CREB1 YY1 and PATZ1 were crucial TFs in the regulatory network of OA These TFs could regulate the DCGs expression to involve RA and OA by promoting or inhibiting their expression Altogether our work may extend our understanding of disease mechanisms and may lead to an improved diagnosis However further experiments are still needed to confirm these observations
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