Intensifying renal replacement therapy during preg

Authors: Kelly L Craig Tiina Podymow Robert P Pauly

Publish Date: 2009/11/24

Volume: 42, Issue: 1, Pages: 137-139

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Abstract

Fertility among women receiving conventional hemodialysis or peritoneal dialysis is very low For those able to conceive it appears that infant survival is poor and prematurity and its related complications are still commonplace Nocturnal hemodialysis NHD is a form of intensive selfadministered hemodialysis whereby patients receive 3–4 times the duration of conventional hemodialysis resulting in superior removal of uremic toxins compared to traditional dialysis modalities NHD has been associated with increased fertility infants with higher birth weights born at more advanced gestational ages and fewer maternal and fetal complications These encouraging results suggest a greater role for much more intensive dialysis in pregnancyPregnant women with endstage renal disease ESRD pose a unique and anxiety provoking challenge to nephrologists and obstetricians alike because pregnancy for dialysisdependent women remains a relatively rare occurrence and because fetal outcomes have been historically poor There are few data quantifying fertility among women receiving dialysis In a registry of 6230 women in the United States between the ages of 14 and 44 years receiving either hemodialysis or peritoneal dialysis between 1992 and 1996 pregnancy was observed in only 2 1 A Belgian study reported an incidence of pregnancy of 03 per hundred patientyears for 1472 women between the ages of 18 and 44 from 1975 to 1996 2 Other studies are more difficult to interpret due to incomplete sampling of disparate source populations and an inconsistent method of defining fertility Fetal outcomes of these rare pregnancies are also poor with successful deliveries observed in 40–50 of cases based on registry or large survey data 1 2 3 Only 0–16 of pregnancies progressed to full term ≥37 weeks gestation and many resulted in birth at 32 weeks gestation amid complications such as low birth weights infantile respiratory distress syndrome retinopathy of prematurity patent ductus arteriosus intraventricular hemorrhage to name just a few 1 2 3 4International Urology and Nephrology has been an ongoing forum for discussing pregnancyrelated issues in ESRD A report by Gumus et al 5 explored the relationship between glomerular filtration rate and parity and found that pregnancyassociated hyperfiltration did not adversely affect kidney function in women with multiple pregnancies A recent report by Smith and colleagues highlighted the utility of intensifying the peritoneal dialysis prescription to include 24h continuous cycler peritoneal dialysis during the third trimester 6 and in the current issue Tuot et al 7 present an interesting case of nutritional support provided to a pregnant woman on hemodialysis with hyperemesis gravidarum using intradialytic parenteral nutrition IDPN The latter two reports underscore the need for increased dialysis dose to mitigate the deleterious effects of the uremic milieu on the developing fetus a practice that is in agreement with expert opinion 8 9 10 Indeed a recent retrospective study of 28 women receiving hemodialysis found that birth weight ≥1500 g and a gestational age ≥32 weeks correlated with maternal blood urea nitrogen levels of 49 and 48 mg/dL respectively 18 and 17 mmol/L 4 This report provides objective evidence supporting the traditional recommendation that dialysis be intensified during pregnancy to achieve a target urea concentration 50 mg/dLThe degree to which renal replacement therapy is to be augmented in order to achieve this goal is relatively arbitrary with consensus opinion suggesting that weekly hemodialysis time be increased to at least 20–24 h 8 9 10 A systematic evaluation of longer weekly treatment on pregnancy outcomes was not available until recently Barua et al 11 at the University of Toronto described their outcomes in a cohort of pregnant women receiving nocturnal home hemodialysis NHD NHD is an intensive form of renal replacement therapy whereby patients selfadminister their hemodialysis on 4–6 nights per week with each session lasting 6–8 h thus patients typically receive 3–4 times the amount of hemodialysis as those undergoing conventional thrice weekly treatments 12 The Toronto experience from 2001 to 2006 describes 7 pregnancies among 45 women of childbearing age 14–44 years receiving NHD at the time of conception Thus 156 of their cohort became pregnant a proportion substantially greater than previous reports The mean weekly duration of NHD at the time of conception was 36 ± 10 h and this was further intensified to 48 ± 5 h after pregnancy was confirmed One pregnancy was electively terminated during the first trimester and all but one of the remaining pregnancies progressed to ≥36 weeks with a mean birth weight of 2418 g Three infants were born by spontaneous vaginal deliveries one was induced and required vacuum extraction and two necessitated delivery by Caesarean section One fetus had evidence of intrauterine growth restriction and was delivered at 36 weeks weighing 2020 g while another was small for gestational age at the 20th percentile and delivered at 30 weeks no other fetal complications were reported With respect to the course of dialysis during pregnancy all women had systolic and diastolic blood pressures within the physiologic range appropriate for stage of gestation two women required treatment with either lowdose methyldopa or lowdose labetolol Hemoglobin was managed with increasing doses of erythropoietin and supplemental iron Due to the long duration of each treatment session and the associated removal of phosphate the dialysate was supplemented with sodium phosphate in all cases Mean predialysis urea concentrations ranged from 21 to 39 mg/dL 76–140 mmol/L while postdialysis urea concentrations ranged from 3 to 9 mg/dL 10–32 mmol/LThis case series of six successful pregnancies among prevalent NHD patients are remarkable in many ways Firstly the fertility of women receiving this intensive form of renal replacement therapy appears to be substantially greater than previously reported Though the 156 proportion of women conceiving while on NHD may well be an overestimation since spontaneous abortions prior to clinical confirmation of pregnancy remain unknown this limitation is true for all other previous reports of fertility statistics and should not obscure the significance of this finding The reason for increased fertility is unknown though presumably related to improved clearance of uremic toxins normalizing the hypothalamicpituitaryovarian axis abnormalities of ESRD 13 Secondly NHD patients achieved higher birth weights and pregnancy duration was longer a marked improvement from previously published literature Finally maternal–fetal complications associated with kidney disease such as intrauterine growth restriction maternal hypertension and polyhydramnios were fewer or not observed This too may be due to minimizing the uremic environment and optimizing fluid balance management The authors concede that a major limitation to their case series is the small sample size and the absence of an appropriate control group However due to the rarity of pregnancy among dialysis patients historical controls from the published literature is not only reasonable but the only realistic approach Hopefully outcomes in larger numbers of NHD patients will support this initially positive reportNotwithstanding the limitations of the Toronto case series the NHD experience has important implications for women with ESRD wishing to conceive or who are already pregnant In view of the traditionally poor maternal–fetal outcomes of pregnancy conception for women on dialysis cannot be encouraged based solely on the results of this singlecase series However for those women adamantly wishing to become pregnant and who are not imminently transplantable a significantly more intensive dialysis regimen should be considered Additionally while all women of childbearing age receiving dialysis therapy should be counseled regarding contraception this is especially true for those receiving NHD whose fertility appears to be much higher than for women receiving conventional dialysis Finally women with ESRD who do become pregnant routinely have their dialysis dose intensified from the usual 12 h per week to greater than 20 h per week in accordance with expert opinion The Toronto experience suggests that weekly dialysis duration 40 h is associated with improved outcomes Though only a few centers have NHD programs even a conventional hemodialysis unit might consider offering prolonged daily dialysis eg 6 weekly sessions lasting 8 h per session using a dialysis prescription similar to NHD Such a timeconsuming commitment to dialysis therapy may seem overwhelming but the prospect of improved maternal–fetal outcomes may prove to be the necessary motivation for expecting mothersHopefully the encouraging outcomes with NHD will prompt consideration of this dialytic paradigm for pregnant women with ESRD by their nephrology and highrisk obstetrical team Broader uptake of NHD for this purpose and additional reports of pregnancy outcomes will better delineate the risks and benefits of NHD in this setting compared to traditional dialysis modalities

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