Authors: C G Musso J Reynaldi B Martinez A Pierángelo M Vilas L Algranati
Publish Date: 2010/07/01
Volume: 43, Issue: 1, Pages: 253-256
Abstract
Decline in glomerular filtration rate GFR is one of several changes in renal physiology in the elderly Renal reserve RR is the kidney′s capacity to increase its basal GFR by at least 20 after a protein overload Even though it has already been reported that RR is preserved in healthy old people there is no information whether RR is also preserved in the healthy very old one older than 74 of age which we decided to study and report our findings in this paperWe studied RR in 16 healthy persons divided into three age groups young 20–40 years old n 5 64–74 years old n 6 and oldest old 74 years old n 5 Renal reserve test was performed by assessing creatinine clearance with cimetidine before and after an oral protein load Statistical analysis was performed using ANOVA testEven though renal reserve response was present in all age groups its magnitude delta GFR was significantly higher in the healthy young group 1036 ± 53 ml/min compared to the old one 341 ± 40 ml/min P = 0002 while it was significantly lower in the healthy oldest old 207 ± 07 ml/min group compared to the other two groups P = 0002
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