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Title of Journal: Int Urol Nephrol

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Abbravation: International Urology and Nephrology

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Springer Netherlands

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DOI

10.1016/0956-716x(95)00414-q

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ISSN

1573-2584

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Organ cross talk and remote organ damage following

Authors: Rele Ologunde Hailin Zhao Kaizhi Lu Daqing Ma
Publish Date: 2014/06/26
Volume: 46, Issue: 12, Pages: 2337-2345
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Abstract

Increasing evidence suggests that acute kidney injury AKI mediates a systemic response that can lead to multiple organ failure AKI may manifest in a variety of clinical scenarios including kidney transplantation and is associated with a significantly high mortality It has been postulated that specific proinflammatory cytokines including IL1β IL6 and TNFα may mediate a systemic response resulting in recruitment of proinflammatory cells leading to organ failure However the specific mechanism by which the cytokine cascade results in distant organ damage is yet to be determined Furthermore it remains unclear as to whether cytokines mediate similar or differing responses in different end organs This review summarizes the effects of AKI on remote organs and explores the role of systemic cytokines in mediating distant organ damage

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