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Title of Journal: Int Urol Nephrol

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Abbravation: International Urology and Nephrology

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Springer Netherlands

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DOI

10.1007/978-0-387-70909-3_24

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ISSN

1573-2584

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The importance of calciuria as lithogenic factors

Authors: Miguel ArrabalMartin Antonio PoyatosAndujar María del Carmen CanoGarcía Miguel QuesadaCharneco Felix AbadMenor María Sierra Girón Prieto Tomás de Haro Muñoz Miguel Angel ArrabalPolo
Publish Date: 2015/02/05
Volume: 47, Issue: 3, Pages: 445-449
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Abstract

Recurrent kidney stones are associated with bone mineral density loss altered bone remodeling markers hypercalciuria and increased in fasting calcium/creatinine ratio The objective was to determine biochemical alterations in urine in patients with osteopenia/osteoporosis without calcium kidney stones compared with patients with calcium kidney stonesThis is a crosssectional study including 142 patients who were divided in two groups Group 1 patients with recurrent calcium kidney stones and Group 2 patients with osteopenia/osteoporosis in the lumbar spine or hip Analyses of bone mineral density calcium–phosphorous and bone metabolism and lithogenic risk factors in fasting urine samples and 24h urine samples were performed Statistical analysis was carried out with SPSS 170 A p ≤ 005 was considered statistically significantPatients in Group 2 presented greater loss of bone mineral density and more elevated alkaline phosphatase iPTH phosphorous and βcrosslaps levels as compared to patients in Group 1 However Group 1 presented greater urine calcium oxalate and uric acid and a higher proportion of hypocitraturia hypercalciuria and hyperoxaluria as compared to Group 2 Multivariate analysis revealed that advanced age and βcrosslaps levels are risk factors for bone mineral density loss while low urinary calcium excretion was protective against bone demineralizationPatients with osteopenia/osteoporosis without lithiasis present some urinary biochemical alterations This would explain the lack of lithogenic activity although low calcium excretion in 24h urine samples is a protective factor against the loss of bone mineral density

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