Authors: Haluk Söylemez Süleyman Kiliç Murat Atar Necmettin Penbegül Ahmet Ali Sancaktutar Yaşar Bozkurt
Publish Date: 2011/07/30
Volume: 44, Issue: 2, Pages: 401-408
Abstract
Forty varicocele patients whom have normal sperm concentration 20 million/ml were involved in the study The patients were divided into two groups such as Daflon n = 20 and placebo n = 20 group Pain score semen analyses and Doppler sonography were performed in all patients before and after the treatmentIn the first group mean pain scores at 1 3 6 and 12 months were 180 ± 132 115 ± 093 105 ± 095 and 095 ± 089 respectively all were significantly lower P 0001 for each than baseline 525 ± 107 While semen volume total sperm count sperm concentration and morphology were not changed significantly the motility of sperm increased significantly P = 0015 due to decrease in grade 1 sperms at the 6th month in the first group Reflux time of left spermatic vein during the Valsalva maneuver decreased significantly P 0001Results of this study suggest the safety and efficacy of Daflon in the treatment of varicoceleassociated pain However these results of the present study must be confirmed by randomized placebocontrolled studies by using different drug doses and durations before making any recommendation for the use of Daflon
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