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Title of Journal: Curr Microbiol

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Abbravation: Current Microbiology

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Springer-Verlag

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DOI

10.1016/0022-3115(92)90588-c

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1432-0991

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Phenotypic and Genetic Characteristics of Macrolid

Authors: Chun Lu Ting lu Ye Guo xing Zhu Pei ying Feng Han Ma Rong biao Lu Wei Lai
Publish Date: 2009/12/31
Volume: 61, Issue: 1, Pages: 44-49
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Abstract

The phenotypic and genetic characteristics of resistance to macrolides and lincosamides among 72 Ureaplasma urealyticum clinical strains isolated in Guangzhou China were investigated in this study Strains were studied by resistance phenotyping detection of resistance genes ermB msrA msrB msrC and msrD and determining the significance of an association between the presence of resistance genes and the intTn gene a genetic marker of transposon The ermB msrA msrB msrC and msrD genes were obtained in 21 1 12 0 and 24 strains respectively The msrB and msrD genes were detected in strains of macrolides M or macrolides–streptogramin B MS resistance phenotype and the ermB gene was detected in strains of M or macrolide–lincosamide ML phenotype in U urealyticum Statistical analysis revealed that only the ermB gene was closely associated with the intTn gene It was concluded that U urealyticum harbored the ermB msrA msrB and msrD genes which confer resistance to macrolides and or lincosamides The ermB gene may be located in the U urealyticum transposonProfessor Xiaoyan Han and the staff of central lab in the Third Hospital of Sun Yatsen University provided technical assistance for this study Dr Joseph Tucker at the Massachusetts General Hospital in Boston USA helped edit an earlier version of this manuscript This work was supported by Natural Science Foundation No 8151008901000108 and Scientific and Technological Planning Project Foundation No 2007B030502013 of Guangdong province China

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