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Title of Journal: Curr Microbiol

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Abbravation: Current Microbiology

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Springer US

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DOI

10.1016/0550-3213(90)90570-4

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1432-0991

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Molecular Analysis of VP7 Gene of Rotavirus G1 Str

Authors: Swapnil Jain Jitendraa Vashistt Kanika Gupta Ashok Kumar Harish Changotra
Publish Date: 2016/08/26
Volume: 73, Issue: 6, Pages: 781-789
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Abstract

Rotavirus G1 strains are the predominant cause of diarrhoea in children Universally common rotavirus vaccines Rotarix and RotaTeq include G1 as the immunological component India has recently introduced rotavirus vaccine in Universal Immunization Programme Therefore in the present study VP7 gene of rotavirus G1 strains circulating in Himachal Pradesh India is analysed to study their phylogenetic characteristics and further comparative analysis was performed for assessment of their divergence from the vaccine strains The rotavirus strains JUSOL5 JUSOL58 JUSOL77 JUSOL173 and JUSHI14 analysed in the study were isolated from the faeces of diarrhoeic children during active surveillance for rotaviruses The Himachal strains clustered together in G1Lineage 1 in the phylogenetic analysis All five isolates showed 964–988  similarity with the other G1Lineage 1 strains at amino acid level However none of them clustered in the predefined sublineages within lineage 1 Interestingly all the strains were distantly related to the vaccine strains having 939–945 and 919–926  similarities at amino acid level with Rotarix and RotaTeq strains respectively The comparative sequence and structural analysis of the Himachal strains with vaccine strains revealed differences in amino acids in epitope region of the protein especially at the antibody neutralization sites The study highlights variations between the G1 strains from Himachal Pradesh India and Rotarix and RotaTeq vaccine strains These differences might have an impact on the neutralization efficiency of vaccine and subsequently on vaccine efficacy This underscores further investigation to study intragenotype antigenic variability and also impact of viral evolution on vaccine effectivenessHC is thankful to Department of Science and Technology Government of India and Department of Biotechnology Government of India respectively for the Grants SB/FT/LS440/2012 and BT/PR6784/GBD/27/466/2012 JV is thankful to Indian Council of Medical Research for Grant 5/9126 201112 ECDII SJ is thankful to Jaypee University of Information Technology Solan Himachal Pradesh India and Indian Council of Medical Research New Delhi India for Junior and Senior Research Fellowships respectively


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