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Title of Journal: Eur Arch Otorhinolaryngol

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Abbravation: European Archives of Oto-Rhino-Laryngology

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Springer-Verlag

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DOI

10.1007/s100640000074

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ISSN

1434-4726

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Safety aspects of subcutaneous immunotherapy with

Authors: C Barth F Anero O Pfaar L Klimek K Hörmann B A Stuck
Publish Date: 2010/05/09
Volume: 267, Issue: 12, Pages: 1873-1879
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Abstract

Polysensitization against a multitude of different allergens is a common problem in the treatment of allergies with specific immunotherapy SIT The aim of this retrospective study was to investigate the risk of simultaneous administration of two allergen extracts during SIT with a conventional or Cluster regimen Local LR and systemic reactions SR in 147 patients receiving different forms of SIT were compared Patients received a total number of 2758 injections during doseincrease phase and 3412 injections during maintenance phase During doseincrease phase a higher rate of LR for 1A 07 and for 2A 15 was found with parallel injections of two allergen extracts 2A The increase of SR was however not significant with conventional for 1A 0 and for 2A 03 or Cluster therapy for 1A 03 and for 2A 05 No increment of SR with injections of two allergen extracts did occur during maintenance phase for 1A 03 and for 2A 01 In conclusion the results of the present study indicate that a higher rate of LR and SR must be considered during doseincrease phase independent of the kind of induction regime used The rate of adverse events AE with two different allergen extracts however seems tolerable After reaching maintenance phase a higher rate of AE with parallel allergen injections did not occur

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