Authors: O Bayer R Cámara S R Zeissig M Ressing A Dietz L D Locati H Ramroth S Singer
Publish Date: 2014/10/14
Volume: 273, Issue: 1, Pages: 9-20
Abstract
The aim of the study was to explore the relationship between occupational exposure defined by occupational categories and job title and laryngeal cancer A systematic review and metaanalysis of 21 tobacco and alcoholadjusted case–control studies including data from 6906 exposed cases and 10816 exposed controls was performed to investigate the frequency of laryngeal cancer in different occupations Job classifications were harmonized using the International Standard Classification of Occupations Pooled odds ratios OR 95 confidence intervals CI were calculated for the different occupational groups A significantly increased risk of laryngeal cancer was observed for the occupational category of ‘productionrelated workers transport equipment operators and laborers’ OR=13 12–14 particularly at risk were occupations as miners OR=16 12–21 tailors OR=17 12–23 blacksmith and toolmakers OR=15 12–17 painters OR=14 11–19 bricklayers and carpenters OR=13 12–15 and transport equipment operators OR=13 12–15 Individuals working as ‘professional technical and related workers’ OR=07 06– 08 ‘administrative and managerial workers’ OR=06 04–07 or ‘clerical and related workers’ OR=08 07–09 had laryngeal cancer less frequently Occupational exposure defined by occupational categories and job title is likely to be an independent risk factor for laryngeal cancer Further research on specific occupations with increased risk of laryngeal cancer is warranted to explore the underlying mechanisms
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