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Title of Journal: Eur Arch Otorhinolaryngol

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Abbravation: European Archives of Oto-Rhino-Laryngology

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Springer Berlin Heidelberg

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DOI

10.1002/sca.4950260608

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ISSN

1434-4726

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Platinuminduced ototoxicity a review of prevaili

Authors: Sofia Waissbluth Emilia Peleva Sam J Daniel
Publish Date: 2016/05/31
Volume: 274, Issue: 3, Pages: 1187-1196
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Abstract

The antineoplastic agent’s cisplatin and carboplatin are widely used as they are highly effective Unfortunately ototoxicity is a frequently encountered side effect of platinumbased chemotherapy Clinically patients generally develop a progressive bilateral and irreversible sensorineural hearing loss With rising cancer survival rates a greater proportion of patients are living with the side effects of their chemotherapy treatments Consequently the quality of life of cancer survivors has now become a major concern for clinicians Various classification systems are currently available to grade side effects and provide a guideline for subsequent treatments An extensive review of the literature revealed that a variety of criteria are used worldwide for grading platinuminduced hearing loss in children and adults including the National Cancer Institute criteria Brock’s grading system the American SpeechHearingLanguage Association criteria the World Health Organization criteria the Pediatric Oncology Group criteria and the Muenster classification Less commonly used criteria include the Chang classification the Functional Hearing Loss scale the HIT system German Hirntumor study grading system and most recently the International Society of Pediatric Oncology Boston ototoxicity grading scale The objective of this review is to evaluate the commonly used ototoxicity criteria and discuss their benefits and limitations

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