Authors: Hesham Negm Mohamed Mosleh Hesham Fathy Ahmed Awad
Publish Date: 2016/05/25
Volume: 273, Issue: 10, Pages: 3237-3241
Abstract
The objective of this study is to investigate thyroid and parathyroid functions in patients with laryngeal carcinoma after total laryngectomy with hemithyroidectomy with or without irradiation and to determine if irradiation when following surgery has an additive effect contributing to either or both glands hypo function This study included 17 patients with laryngeal squamous cell carcinoma who were subjected to surgery Nine of them were further justified for postoperative radiotherapy as well All patients were subjected to Clinical assessment including adequate history taking and physical examination to detect the presence of hypothyroidism or hypoparathyroidism Laboratory assessment of thyroid function included TSH and T4 assay and parathyroid function included corrected serum calcium and parathormone levels Eight 48 patients were treated with surgery alone and 9 52 patients received postoperative radiotherapy In this study 13 out of the 17 patients 78 were found to be hypothyroid and 4 22 were euthyroid while 7 42 were found to have hypoparathyroidism The study showed among the 8 patients who were treated by surgery only 5 625 of them developed hypothyroidism and 3 375 were euthyroid and 3 375 developed hypoparathyroidism and 5 625 were normal Among the 9 patients who were treated by surgery and radiotherapy 8 889 developed hypothyroidism and 1 111 was euthyroid and 4 444 developed hypoparathyroidism and 5 556 were normal The study confirms the development of hypothyroidism with or without hypoparathyroidism after total laryngectomy with a higher incidence in those treated by combined surgery and radiotherapy and in supraglottic tumors
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