Authors: XiaoBin Zhang XingTang Jiang FangRong Cai HuiQing Zeng YanPing Du
Publish Date: 2016/05/28
Volume: 274, Issue: 2, Pages: 661-670
Abstract
Published articles regarding the blood levels of vascular endothelial growth factor VEGF in obstructive sleep apnea OSA patients are contradictory The objective of this study was to explore whether VEGF levels is high or not in OSA subjects via quantitatively statistical analysis The electronic databases of Pubmed Web of Science EMBASE were systematic searched The VEGF levels and clinical characteristics of participants between OSA group and control group were extracted for analysis Weighted mean difference WMD or standard mean difference SMD with 95 confidence interval CI was calculated by fixed effects or random effects model Appropriate statistical software was employed for data synthesis Totaling 15 articles with 697 participants were included in this study Pooled metaanalysis showed that blood VEGF concentrations were significantly higher in OSA patients than in control subjects SMD 189 95 CI 092–287 p = 0000 Subgroup analysis demonstrated that when compared with control group OSA patients with age ≥50 years SMD 254 95 CI 128–380 p = 0000 apnea hypopnea index ≥30 events/h SMD 247 95 CI 120–373 p = 0000 had higher VEGF levels Compared with control subjects OSA patients had an elevated VEGF in serum SMD 355 95 CI 182–528 p = 0000 rather than in plasma High blood VEGF concentrations were observed in OSA patients particularly in the older and more serious patients
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